Clinical Profile of Alzheimer’s Disease Non-Responder Patient

Alzheimer’s disease (AD) is a disabling neurodegenerative disorder typical of old age. Recent advances led to the development of drugs which effectively alleviate cognitive symptoms. About one-third of patients however do not respond to current pharmacological treatment (Ryu et al., 2005). Reasons of such lack of efficacy of available drugs may represent a step ahead in the understanding of this disabling disorder. To define a non responder profile is the aim of this work. Accordingly, authors will deal with pathogenesis of AD, neuro-behavioural symptoms, brain imaging and CSF characteristics in order to extract from each section the most relevant features helpful for identification of non responder profile. Such work is difficult and may meet disagreement among specialists, however authors strongly believe that this work may represent a sort of starting point contributing to better understand AD pathophysiology.